📄 Category

pharmacology and toxicology

111 papers

Pharmacology and toxicology explore how substances interact with living systems, ranging from the development of life-saving medicines to understanding the dangers of chemical exposure. This field sits at the critical intersection of chemistry and biology, asking essential questions about how drugs work, how the body processes them, and what happens when things go wrong. It is a dynamic area where researchers constantly strive to improve patient safety while discovering new therapeutic possibilities.

At Gist.Science, we bridge the gap between complex research and public understanding by curating the latest preprints from bioRxiv in this vital category. Our team processes every new submission from bioRxiv as it appears, transforming dense scientific data into both plain-language overviews and detailed technical summaries. This ensures that whether you are a specialist or a curious reader, you can grasp the significance of these emerging findings without getting lost in jargon.

Below are the most recent pharmacology and toxicology papers from bioRxiv, each accompanied by our expert analysis to help you navigate the latest scientific breakthroughs.

📄 pharmacology and toxicology

Tunneling Effect with Time-Dependent Effective Potential Barrier: A Semiclassical (WKB) Reinterpretation of Drug Release Kinetics in Polymeric Nanocapsules

This paper proposes a semiclassical reinterpretation of drug release kinetics in polymeric nanocapsules by modeling the potential barrier as a time-decaying function rather than a static one, demonstrating through global optimization of ex-vivo data that an exact transmission formula combined with an exponential decay hypothesis provides a superior and more parsimonious fit than previous multifractal or rational decay models.

de Albuquerque, D. F., de Albuquerque, M. A. S.2026-08-05
📄 pharmacology and toxicology

Comparative Analysis of Ultrafine Particulate Matter, Black Carbon, and Polystyrene Nanoplastics Identifies Mitochondrial Stress Adaptation as a Conserved Mechanism of Immunotoxicity

This study demonstrates that despite distinct physicochemical properties and kinetic profiles, ultrafine particulate matter, black carbon, and polystyrene nanoplastics all induce immunotoxicity through a conserved mitochondrial stress response network centered on the OMA1-DELE1 axis, while also exhibiting particle-specific dynamics that determine the severity and persistence of cellular damage.

Mishra, P. K., Chouksey, A., Rajan, A. K., Gurjar, V., Pathak, A., Aglawe, A., Tiwari, R. P., Dash, D., Dwivedi, P. P. (…)2026-08-04
📄 pharmacology and toxicology

Evaluation of Anthropogenic influence on surface water quality and its ecological risk in the Ahafo Ano Southwest District

This study evaluates the anthropogenic impact on surface water quality in Ghana's Ahafo Ano Southwest District, revealing significant seasonal and spatial variations driven by agriculture, mining, and deforestation that degrade water quality and pose ecological risks to aquatic life.

Azanu, D., Gyebi, A. S. A., Nutsuklo, S. M., Marfo, S. Y., Aidoo, I. A., Nyarkoh, F., Barimah, E., Tilahun, S. A., Aduse (…)2026-08-04
📄 pharmacology and toxicology

Evaluation of ivermectin effectiveness under contrasting anthelmintic resistance scenarios in beef cattle: a comparative study in Italy and Argentina

This comparative study demonstrates that while ivermectin exhibits similar pharmacokinetic profiles in both young and adult cattle, its therapeutic efficacy varies drastically between Argentina and Italy due to widespread anthelmintic resistance in Argentine farms versus high susceptibility in Italian herds, underscoring the critical need for resistance diagnostics before treatment.

Canton, C., Bosco, A., Maurelli, M. P., Vitiello, P., Ceballos, L., Dominguez, P., Moriones, L., Torres, J. M., Alvarez (…)2026-07-31
📄 pharmacology and toxicology

Predicting tuberculosis relapse based on 28-day CFU, RS ratio, and/or drug contribution for novel regimens in the relapsing mouse model

This study developed and validated a computational model that accurately predicts long-term tuberculosis relapse in mice using only 4-week data on colony-forming units and ribosomal RNA synthesis ratios, thereby enabling the efficient screening and prioritization of novel short-course treatment regimens.

van Wijk, R. C., Solans, B. P., Chaba, L., Sordello, S., Upton, A. M., Nuermberger, E. L., Robertson, G. T., Walter, N. (…)2026-07-30
📄 pharmacology and toxicology

Endocannabinoid ligands (CBD, Δ9THC, and Terpenes) inhibit excitability of mouse dorsal root ganglion neurons and exhibit synergistic inhibitory effects

This study demonstrates that cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and terpenes individually and synergistically inhibit the excitability of mouse dorsal root ganglion neurons through receptor-dependent and indirect mechanisms, supporting the potential of multi-component cannabis formulations as effective non-opioid analgesics.

Choudhury, H., Nicola, M., Greenland, B. W., Guest, D., Spencer, J., Dilley, A.2026-07-22